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CISDOC database

Document ID (ISN)112291
CIS number 12-0117
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2011
Convention or series no.
Author(s) Zeka A., Gore R., Kriebel D.
Title The two-stage clonal expansion model in occupational cancer epidemiology: Results from three cohort studies
Bibliographic information Sep. 2011, Vol.68, No.9, p.618-624. Illus. 48 ref.
Internet access The_two-stage_clonal_expansion_model_[BUY_THIS_ARTICLE] [in English]
Abstract The objective of this work was to apply the two-stage clonal expansion model, with the intention to expand the literature on epidemiological applications of the model and demonstrate the feasibility of incorporating biologically based modelling methods into the widely used retrospective cohort study. The two-stage clonal expansion model was fitted to three occupational cohorts: textile workers exposed to asbestos and followed for lung cancer mortality; diatomaceous earth workers exposed to silica and also followed for lung cancer mortality; automotive manufacturing workers exposed to straight metalworking fluid (MWF) and followed for larynx cancer incidence. The model allowed estimating exposure effects in three stages: cancer initiation (early effects), promotion or malignant transformation (late effects). The findings for asbestos and silica were essentially confirmatory, supporting evidence for their early effects on lung cancer from a large body of literature. The effect of straight MWF on laryngeal cancer was less clear.
Descriptors (primary) epidemiology; cancer; lymphocytes; cohort study; literature survey
Descriptors (secondary) silica; asbestos; cutting fluids; laryngeal cancer; lung cancer; reliability; motor vehicle industry; description of technique
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Cancer and carcinogens