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CISDOC database

Document ID (ISN)112277
CIS number 12-0032
ISBN(s) 978-3-7776-1475-5
Year 2006
Convention or series no. BUA Report 252
Gesellschaft Deutscher Chemiker (GDCh), Advisory Committee on Existing Chemicals (BUA)
Title 2,4-Difluoronitrobenzene
Bibliographic information Hirzel Verlag, Birkenwaldstrasse 44, 70191 Stuttgart, Germany, 2006. xiv, 27p. Bibl.ref. Price: EUR 36.00.
Internet access BUA_Report_252_Summary_[INTERNET_FREE_ACCESS] [in English]
BUA_Report_252_[BUY_THIS_DOCUMENT].pdf [in English]
Abstract Conclusions of this criteria document which reflects the state of knowledge as of July 2004: 2,4-difluoronitrobenzene can be absorbed orally, dermally and by inhalation. In the rat, the oral LD50 is about 200 mg/kg and the dermal LD50 84 mg/kg. In general, the symptoms after acute 2,4-difluoronitrobenzene uptake are staggering, spasms, tremor, accelerated respiration or breathing sounds. Oral administration of 2,4-difluoronitrobenzene also leads to the formation of methemoglobin and Heinz bodies, whereas dermal administration causes cyanosis. Investigations are lacking on the toxicity after repeated uptake. After an exposure period of 15 minutes, undiluted 2,4-difluoronitrobenzene does not irritate the skin. 2,4-Difluoronitrobenzene is slightly irritating to the rabbit eye. Studies on the allergenic effect are not available. Considering the structural similarity to such substances as 3-chloro-2,4-difluoronitrobenzene, a sensitizing potential cannot be ruled out. Data are not available on the reproductive toxicity. Against the backdrop of the fertility-damaging effects of other nitro-aromatics, an effect on the reproductive capacity cannot be excluded. 2,4-Difluoronitrobenzene is positive in the mutagenicity test with Salmonella typhimurium. No other investigations are available on the in vitro or in vivo genotoxicity in mammalian cells or on the carcinogenic potential. However a carcinogenic potential cannot be ruled out, considering the similarity to other nitro-aromatics. Other findings are discussed.
Descriptors (primary) Germany; fluorinated nitrobenzenes; toxicology; ecotoxicology
Descriptors (secondary) mutagens; toxic substances; sensitizers; skin absorption; animal experiments; in vitro experiments; literature survey; criteria document
Document type B - Chemical safety information sheets
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Toxicology
Aromatic hydrocarbons
Halogenated hydrocarbons