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Document ID (ISN)112276
CIS number 12-0031
ISBN(s) 978-3-7776-1476-2
Year 2006
Convention or series no. BUA Report 253
Gesellschaft Deutscher Chemiker (GDCh), Advisory Committee on Existing Chemicals (BUA)
Title 3,7-Dimethyloctane-3-ol
Bibliographic information Hirzel Verlag, Birkenwaldstrasse 44, 70191 Stuttgart, Germany, 2006. xiv, 53p. Bibl.ref. Price: EUR 47.00.
Internet access BUA_Report_253_Summary_[INTERNET_FREE_ACCESS] [in English]
BUA_Report_253_[BUY_THIS_DOCUMENT] [in English]
Abstract Conclusions of this criteria document which reflects the state of knowledge as of September 2004: 3,7-dimethyloctane-3-ol is of low acute toxicity. Eight-hour exposure to an atmosphere enriched with 3,7-dimethyloctane-3-ol does not cause symptoms of poisoning in rats. The oral and dermal LD50 in rats is higher than 200 mg/kg. Symptoms of poisoning after oral uptake are dyspnoea, apathy, lateral position, staggering, atony, narcotic condition with an absence of pain and corneal reflexes, a spastic gait, diarrhoea, salivation and lacrimation. In rabbits, 3,7-dimethyloctane-3-ol causes slight-to-moderate irritation to the skin and moderate irritation to the eye. In the maximization test in humans, a 4 % solution does not cause irritation or sensitization after 48-hour occlusive application. 3,7-Dimethyloctane-3-ol is not mutagenic in the mutagenicity test with various Salmonella typhimurium strains and V79 cells. It does not cause chromosome aberrations in V79 cells. Studies on the carcinogenic potential of 3,7-dimethyloctane-3-ol are not available. Other findings are discussed.
Descriptors (primary) Germany; aliphatic alcohols; toxicology; ecotoxicology
Descriptors (secondary) irritation; animal experiments; literature survey; criteria document
Document type B - Chemical safety information sheets
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Alcohols