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CISDOC database

Document ID (ISN)112239
CIS number 11-0818
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Convention or series no.
Author(s) Wang W., Qiu Y.L., Jiao J., Liu J., Ji F., Miao W.B., Zhu Y., Xia Z.L.
Title Genotoxicity in vinyl chloride-exposed workers and its implication for occupational exposure limit
Bibliographic information 2011, Vol.54, p.800-810. 55 ref.
Internet access Genotoxicity.pdf [in English]
Abstract In this case-control study, genetic damage in vinyl chloride monomer (VCM workers was evaluated in relation to their occupational cumulative exposure to VCM. Cytokinesis-block micronucleus assay was conducted in 229 VCM workers and 138 controls to detect chromosome damage in peripheral blood lymphocytes. The cumulative exposure dose (CED) of VCM was calculated based on the job type and duration of each worker and the workplace VCM concentration. Dose-response relationships between VCM CED and micronucleus frequency or chromosomal damage were evaluated, and benchmark doses (BMDs) estimated. Dose-response relationships between VCM CED and chromosomal damage were obtained. It is concluded that VCM exposure may induce chromosomal damage at occupational exposure levels below the Chinese national occupational health standard. Implications of these findings are discussed.
Descriptors (primary) vinyl chloride; DNA; lymphocytes; dose-response relationship; chromosome changes
Descriptors (secondary) China; polyvinyl chloride; exposure evaluation; case-control study; statistical evaluation; threshold limit values; chemical industry
Document type D - Periodical articles
Subject(s) Chemicals, plastics and rubber
Toxic and dangerous substances
Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Chemical safety
Browse category(ies) Exposure evaluation
Chemical industry