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Document ID (ISN)112211
CIS number 11-0808
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2010
Convention or series no.
Author(s) Loomis D., Dement J., Richardson D., Wolf S.
Title Asbestos fibre dimensions and lung cancer mortality among workers exposed to chrysotile
Bibliographic information Sep. 2010, Vol.67, No.9, p.580-584. 25 ref.
Abstract The objective of this study was to estimate exposures to asbestos fibres of specific sizes among asbestos textile manufacturing workers exposed to chrysotile using data from transmission electron microscopy (TEM) and to evaluate the extent to which the risk of lung cancer varies with fibre length and diameter. A total of 3803 workers employed between 1950 and 1973 at one of three plants that produced asbestos textile products were followed for vital status until 31 December 2003. Historical exposures to asbestos fibres were estimated from work histories and 3578 industrial hygiene measurements taken in 1935-1986. Exposure-response relationships for lung cancer were examined within the cohort using Poisson regression. Indicators of fibre length and diameter obtained by TEM were positively and significantly associated with increasing risk of lung cancer. Exposures to longer and thinner fibres tended to be most strongly associated with lung cancer, and models for these fibres fit the data best. Simultaneously modelling indicators of cumulative mean fibre length and diameter yielded a positive coefficient for fibre length and a negative coefficient for fibre diameter.
Descriptors (primary) chrysotile; mortality; cancer; hazard evaluation; asbestos processing industry; job-exposure relation
Descriptors (secondary) USA; particle size; exposure evaluation; cohort study; statistical evaluation
Document type D - Periodical articles
Subject(s) Occupational pathology
Toxic and dangerous substances
Broad subject area(s) Occupational medicine, epidemiology
Chemical safety
Browse category(ies) Cancer and carcinogens
Asbestos