|Document ID (ISN)||112132|
|ISSN - Serial title
||1745-6673 - Journal of Occupational Medicine and Toxicology
|Convention or series no.
||Wilken D., Velasco Garrido M., Manuwald U., Baur X.
||Lung function in asbestos-exposed workers, a systematic review and meta-analysis
||2011, 6:21, 16p. Illus. 83 ref.
||Lung_function.pdf [in English]
||This systematic review was conducted to assess whether asbestos exposure is related to impairment of lung function parameters independently of the radiological findings. Meta-analyses with data from 9,921 workers exposed to asbestos demonstrates a statistically significant reduction in VC, FEV1 and FEV1 /VC, even among those workers without radiological changes. Less severe lung function impairments are detected if the diagnoses are based on (high resolution) computed tomography rather than the less sensitive X-ray images. The degree of lung function impairment was partly related to the proportion of smokers included in the studies. It is concluded that asbestos exposure is related to restrictive and obstructive lung function impairment. The trend for functional impairment persists even in the absence of radiological evidence of parenchymal or pleural diseases.
||asbestos; pulmonary function; spirometry
||smoking; pleural diseases; one-second forced expiratory volume; maximal expiratory flow; chest radiography; tomography; literature survey
||D - Periodical articles
Toxic and dangerous substances
|Broad subject area(s)
||Occupational medicine, epidemiology