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Document ID (ISN)112132
CIS number 11-0790
ISSN - Serial title 1745-6673 - Journal of Occupational Medicine and Toxicology
Year 2011
Convention or series no.
Author(s) Wilken D., Velasco Garrido M., Manuwald U., Baur X.
Title Lung function in asbestos-exposed workers, a systematic review and meta-analysis
Bibliographic information 2011, 6:21, 16p. Illus. 83 ref.
Internet access Lung_function.pdf [in English]
Abstract This systematic review was conducted to assess whether asbestos exposure is related to impairment of lung function parameters independently of the radiological findings. Meta-analyses with data from 9,921 workers exposed to asbestos demonstrates a statistically significant reduction in VC, FEV1 and FEV1 /VC, even among those workers without radiological changes. Less severe lung function impairments are detected if the diagnoses are based on (high resolution) computed tomography rather than the less sensitive X-ray images. The degree of lung function impairment was partly related to the proportion of smokers included in the studies. It is concluded that asbestos exposure is related to restrictive and obstructive lung function impairment. The trend for functional impairment persists even in the absence of radiological evidence of parenchymal or pleural diseases.
Descriptors (primary) asbestos; pulmonary function; spirometry
Descriptors (secondary) smoking; pleural diseases; one-second forced expiratory volume; maximal expiratory flow; chest radiography; tomography; literature survey
Document type D - Periodical articles
Subject(s) Occupational pathology
Toxic and dangerous substances
Broad subject area(s) Occupational medicine, epidemiology
Chemical safety
Browse category(ies) Asbestos