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Document ID (ISN)112086
CIS number 11-0675
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2011
Convention or series no.
Author(s) Boffetta P., Fontana L., Stewart P., Zaridze D., Szeszenia-Dabrowska N., Janout V., Bencko V., Foretova L., Jinga V., Matveev V., Kollarova H., Ferro G., Chow W.H., Rothman N., van Bemmel D., Karami S., Brennan P., Moore L.E.
Title Occupational exposure to arsenic, cadmium, chromium, lead and nickel, and renal cell carcinoma: A case-control study from Central and Eastern Europe
Bibliographic information Oct. 2011, Vol.68, No.10, p.723-728. 37 ref.
Abstract The objective of this study was to investigate the risk of renal cell carcinoma (RCC) in Central and Eastern Europe in relation to exposure to known and suspected carcinogenic metals. During 1999-2003, a hospital-based study was conducted in the Czech Republic, Poland, Romania and Russia, including 1097 cases of RCC and 1476 controls. Occupational exposure to arsenic, cadmium, chromium, lead and nickel was assessed by teams of local industrial hygiene experts, based on detailed occupational questionnaires. The odds ratios (ORs) for RCC were 1.55 for exposure to lead and 1.40 for exposure to cadmium. No clear monotonic exposure-response relation was apparent for either duration of exposure or cumulative exposure to either metal, although the OR for the highest category of cumulative exposure to lead was 2.25. Exposure to other metals did not entail an increased risk of RCC.
Descriptors (primary) chromium and compounds; nickel and compounds; arsenic and compounds; cadmium and compounds; lead and compounds; renal cancer; risk factors
Descriptors (secondary) Czech Republic; Poland; Romania; Russian Federation; exposure evaluation; questionnaire survey; case-control study; statistical evaluation; job-exposure relation
Document type D - Periodical articles
Subject(s) Occupational pathology
Toxic and dangerous substances
Broad subject area(s) Occupational medicine, epidemiology
Chemical safety
Browse category(ies) Cancer and carcinogens
Cadmium and compounds
Arsenic and compounds
Lead and compounds
Nickel and compounds