|Document ID (ISN)||112085|
|ISSN - Serial title
||1351-0711 - Occupational and Environmental Medicine
|Convention or series no.
||Calvert G.M., Ruder A.M., Petersen M.R.
||Mortality and end-stage renal disease incidence among dry cleaning workers
||Oct. 2011, Vol.68, No.10, p.709-716. 37 ref.
||Perchloroethylene (PCE) is a known animal carcinogen and probable human carcinogen. Dry cleaning exposures, particularly PCE, are also associated with renal toxicity. The objective was to follow-up a cohort of dry cleaners to evaluate mortality and assess end-stage renal disease (ESRD) morbidity. This study adds eight years of mortality follow-up for 1704 dry cleaning workers in four United States cities. Employees eligible for inclusion worked for ≥1 year before 1960 in a shop using PCE as the primary solvent. Life table analyses for mortality and ESRD morbidity were conducted. Only employees alive on 1 January 1977 were included in ESRD analyses. Overall cancer deaths were in significant excess in this cohort (standardized mortality ratio (SMR) 1.22). Oesophageal, lung and tongue cancers had significant excesses of deaths. Oesophageal cancer risk was highest among those employed in a PCE-using shop for ≥5 years with ≥20 years' latency since first such employment. Deaths from non-malignant underlying diseases of the stomach and duodenum were in significant excess. Hypertensive ESRD morbidity was significantly elevated in the entire cohort (standardized incidence ratio (SIR) 1.98), and among workers employed only in PCE-using dry cleaning shops for ≥5 years.
||tetrachloroethylene; dry cleaning; mortality; renal diseases; risk factors
||USA; latency; tongue diseases; oesophageal carcinoma; lung cancer; hazard evaluation; long-term study; cohort study; statistical evaluation; long-term exposure
||D - Periodical articles
||Commerce, services, offices
Toxic and dangerous substances
|Broad subject area(s)
||Occupational medicine, epidemiology
||Cancer and carcinogens
Laundries and dry cleaning