ILO Home
Go to the home page
Site map | Contact us Français | Español

CISDOC database

Document ID (ISN)111940
CIS number 11-0528
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2010
Convention or series no.
Author(s) Labrèche F., Goldberg M.S., Valois M.F., Nadon L.
Title Postmenopausal breast cancer and occupational exposures
Bibliographic information Apr. 2010, Vol.67, No.4. p.263-269. 47 ref.
Abstract The objective of this study was to determine whether exposures in the workplace to organic solvents and to other agents, such as polycyclic aromatic hydrocarbons, are associated with increased risks of developing postmenopausal breast cancer. It was conducted in the form of a case-control study in Montreal, Canada. Cases comprised 556 women, aged 50-75 years, with incident malignant breast cancer, while controls were 613 women with other cancers, frequency-matched for age and time of diagnosis. An expert team of chemists and industrial hygienists translated their job histories into exposure to about 300 agents. Increased odds ratios (ORs) were found for each 10-year increment in duration of exposure, before age 36 years (OR(<36)), to acrylic fibres (OR(<36) 7.69) and to nylon fibres (OR(<36) 1.99). For oestrogen-positive and progesterone-negative tumours, the OR doubled or more for each 10-year increase in exposure to mono-aromatic hydrocarbons, and to acrylic and rayon fibres. The OR(<36) also doubled for exposure to organic solvents that metabolise into reactive oxygen species, and to acrylic fibres. A threefold increase was found for oestrogen- and progesterone-positive tumours, with exposure to polycyclic aromatic hydrocarbons from petroleum sources. Findings are consistent with the hypothesis that breast tissue is more sensitive to adverse effects if exposure occurs when breast cells are still proliferating.
Descriptors (primary) Quebec; breast cancer; menopause; chemical hazards; risk factors
Descriptors (secondary) Canada; aromatic hydrocarbons; polyamides; polyacrylonitrile; solvents; exposure evaluation; case-control study; synthetic fibre industry
Document type D - Periodical articles
Subject(s) Occupational pathology
Toxic and dangerous substances
Broad subject area(s) Occupational medicine, epidemiology
Chemical safety
Industries and occupations
Browse category(ies) Cancer and carcinogens