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Document ID (ISN)111925
CIS number 11-0520
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 2011
Convention or series no.
Author(s) Nogueira C.R., Nápolis L.M., Bagatin E., Terra-Filho M., Müller N.L., Silva C.I.S., Rodrigues R.T., Neder J.A, Nery L.E.
Title Lung diffusing capacity relates better to short-term progression on HRCT abnormalities than spirometry in mild asbestosis
Bibliographic information 2011, Vol.54, p.185-193. Illus. 45 ref.
Abstract Pulmonary function tests (PFT), particularly spirometry and lung diffusing capacity for carbon monoxide (DLCO), have been considered useful methods for the detection of the progression of interstitial asbestos abnormalities as indicated by high-resolution computed tomography (HRCT). However, it is currently unknown which of these two tests correlates best with anatomical changes over time. In this study, longitudinal changes (3-9 years follow-up) in PFTs were compared at rest and during exercise with interstitial abnormalities evaluated by HRCT in 63 ex-workers with mild-to-moderate asbestosis. At baseline, patients presented with low-grade asbestosis and most PFT results were within the limits of normality. In the follow-up, most subjects had normal spirometry, static lung volumes and arterial blood gases. In contrast, frequency of DLCO abnormalities almost doubled. Twenty-three subjects increased the interstitial marks on HRCT. These had significantly larger declines in DLCO compared to patients who remained stable (0.88 vs. 0.31ml/min/mm Hg/year and 3.5 vs. 1.2%/year, respectively). However, no between-group differences were found for the other functional tests, including spirometry. These data demonstrate that the functional consequences of progression of HRCT abnormalities in mild-to-moderate asbestosis are better reflected by decrements in DLCO than by spirometric changes. These results might have important practical implications for medico-legal evaluation of this patient population.
Descriptors (primary) diagnosis; asbestosis; diffusion capacity; spirometry; medical supervision
Descriptors (secondary) respiratory function tests; tomography; reliability; description of technique
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Asbestos