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Document ID (ISN)111924
CIS number 11-0519
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 2010
Convention or series no.
Author(s) Phillips J.I., Green F.Y., Davies J.C., Murray J.
Title Pulmonary and systemic toxicity following exposure to nickel nanoparticles
Bibliographic information 2010, Vol.53, p.763-767. Illus. 24 ref.
Abstract Nanoparticles are being used in ever increasing numbers in a range of industrial and medical products. Questions surrounding their potential to cause toxic effects in humans have been raised. Although animal experiments predict that nanoparticles are more toxic than their larger counterparts there are few descriptions in the literature of human exposure. A case described in 1994 has been re-examined from a pathology perspective. The subject, a 38-year-old previously healthy male, inhaled nanoparticles of nickel while spraying nickel using a metal arc process. He died 13 days after being exposed and the cause of death at autopsy was adult respiratory distress syndrome (ARDS). Nickel particles <25 nm in diameter were identified in lung macrophages using transmission electron microscopy. High levels of nickel were measured in his urine and his kidneys showing evidence of acute tubular necrosis.
Descriptors (primary) nickel; nanoparticles; metal coating; inhalation toxicity
Descriptors (secondary) diagnosis; respiratory diseases; histopathology; autopsy; fatalities; case study
Document type D - Periodical articles
Subject(s) Metal production and metalworking
Toxic and dangerous substances
Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Chemical safety
New technologies
Browse category(ies) Nickel and compounds
Toxicology
Pneumoconioses
Nanotechnology and nanoparticles