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Document ID (ISN)111788
CIS number 11-0370
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 2011
Convention or series no.
Author(s) Richardson D.B., Wing S.
Title Evidence of confounding by smoking of associations between radiation and lung cancer mortality among workers at the Savannah River Site
Bibliographic information 2011, Vol.54, p.421-427. 25 ref.
Abstract This study investigates confounding by cigarette smoking in the associations between occupational exposure to ionizing radiation and lung cancer mortality among workers at the Savannah River Site (SRS), a facility in the United States involved in the production of basic materials used in the fabrication of nuclear weapons, primarily tritium and plutonium-239. Thirteen thousand two hundred sixty-five white males hired at SRS between 1950 and 1986 were followed through 2002 to ascertain causes of death. Estimates of radiation doses from external sources and internal tritium uptakes were derived from dosimetry records. Logistic regression methods were used to derive discrete-time estimates of rate ratios. Prior to adjustment for smoking, there was minimal evidence of association between lung cancer mortality and cumulative radiation dose under a 10-year lag assumption. Subsequent to indirect adjustment for smoking, the association between lung cancer mortality and cumulative radiation dose under a 10-year lag was positive.
Descriptors (primary) ionizing radiation; nuclear fuel processing; mortality; smoking; lung cancer; confounding factors
Descriptors (secondary) USA; exposure evaluation; long-term study; statistical evaluation; long-term exposure
Document type D - Periodical articles
Subject(s) Radiation
Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Physical hazards
Browse category(ies) Cancer and carcinogens
Diseases of the respiratory system (except for pneumoconiosis & similar)
Ionizing radiation
Other