|Document ID (ISN)||111782|
|ISSN - Serial title
||0271-3586 - American Journal of Industrial Medicine
|Convention or series no.
||Friesen M.C., Costello S., Thurston S.W., Eisen E.A.
||Distinguishing the common components of oil- and water-based metalworking fluids for assessment of cancer incidence risk in autoworkers
||2011, Vol.54, p.450-460. Illus. 42 ref.
||The various types of metalworking fluids (MWFs) have overlapping components. This study derived constituent-based metrics of polycyclic aromatic hydrocarbons (PAHs), water-based MWF, biocides and nitrosamines to account for this overlap and examined their relations with cancer incidence. An autoworkers cohort of 30,000 was followed for cancer incidence. Hazard ratios for each cancer and cumulative exposures were estimated. For most cancer sites, the constituent-based metrics resulted in stronger exposure-disease associations than the MWF classes alone. Laryngeal and bladder cancer were most strongly associated with PAH. Protective effects for stomach and lung cancer were observed with biocide, a component that may be a surrogate for endotoxin. These findings provide support and clarification of possible etiologies for previous positive associations and provide support for distinguishing exposure from oil- and water-based MWF in epidemiologic studies.
||cutting fluids; cancer; motor vehicle industry
||aromatic hydrocarbons; polycyclic hydrocarbons; nitroso amines; biocides; exposure evaluation; cohort study; frequency rates
||D - Periodical articles
||Metal production and metalworking
Toxic and dangerous substances
|Broad subject area(s)
||Occupational medicine, epidemiology
||Cancer and carcinogens
Motor vehicle manufacturing industry