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CISDOC database

Document ID (ISN)111782
CIS number 11-0367
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 2011
Convention or series no.
Author(s) Friesen M.C., Costello S., Thurston S.W., Eisen E.A.
Title Distinguishing the common components of oil- and water-based metalworking fluids for assessment of cancer incidence risk in autoworkers
Bibliographic information 2011, Vol.54, p.450-460. Illus. 42 ref.
Abstract The various types of metalworking fluids (MWFs) have overlapping components. This study derived constituent-based metrics of polycyclic aromatic hydrocarbons (PAHs), water-based MWF, biocides and nitrosamines to account for this overlap and examined their relations with cancer incidence. An autoworkers cohort of 30,000 was followed for cancer incidence. Hazard ratios for each cancer and cumulative exposures were estimated. For most cancer sites, the constituent-based metrics resulted in stronger exposure-disease associations than the MWF classes alone. Laryngeal and bladder cancer were most strongly associated with PAH. Protective effects for stomach and lung cancer were observed with biocide, a component that may be a surrogate for endotoxin. These findings provide support and clarification of possible etiologies for previous positive associations and provide support for distinguishing exposure from oil- and water-based MWF in epidemiologic studies.
Descriptors (primary) cutting fluids; cancer; motor vehicle industry
Descriptors (secondary) aromatic hydrocarbons; polycyclic hydrocarbons; nitroso amines; biocides; exposure evaluation; cohort study; frequency rates
Document type D - Periodical articles
Subject(s) Metal production and metalworking
Toxic and dangerous substances
Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Chemical safety
Browse category(ies) Cancer and carcinogens
Aromatic hydrocarbons
Polycyclic hydrocarbons
Motor vehicle manufacturing industry