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CISDOC database

Document ID (ISN)111742
CIS number 11-0403
ISSN - Serial title 0019-8366 - Industrial Health
Year 2011
Convention or series no.
Author(s) Kim J.H., Moon J.Y., Park E.Y, Lee K.H., Hong Y.C.
Title Changes in oxidative stress biomarker and gene expression levels in workers exposed to volatile organic compounds
Bibliographic information Jan. 2011, Vol.49, No.1, p.8-14. Illus. 28 ref.
Internet access Changes_in_oxidative_stress_biomarker.pdf [in English]
Abstract This study was conducted to evaluate the change of oxidative stress biomarker and gene expression levels in workers exposed to volatile organic compounds. Urine and blood samples were collected from 21 subjects before and after occupational exposure to VOCs. Muconic (MuA), hippuric (HA) mandelic (MaA) and methyl hippuric (MHA) acid were measures as urinary exposure biomarkers for benzene, toluene, ethylbenzene and xylene (collectively BTEX), while malondialdehyde (MDA) and 8-hydroxydeoxyguanine (8-OHdG) were measured as oxidative stress biomarkers in all subjects. BTEX-mediated RNA expression using cDNA microarray were also evaluated in 14 subjects. Findings are discussed. The study results suggest that exposure to VOCs, specifically toluene, induces oxidative stress and various gene expression changes, some being possibly responsible for oxidative stress.
Descriptors (primary) Korea, Republic of; organic compounds; DNA; volatile substances; oxidation; shipbuilding industry; genetic effects
Descriptors (secondary) benzene; toluene; xylene; ethylbenzene; malonaldehyde; determination in blood; determination in urine; statistical evaluation
Document type D - Periodical articles
Subject(s) Metal production and metalworking
Broad subject area(s) Chemical safety
Browse category(ies) Shipbuliding and ship repair
Aromatic hydrocarbons