|Document ID (ISN)||111648|
|ISSN - Serial title
||0355-3140 - Scandinavian Journal of Work, Environment and Health
|Convention or series no.
||Mehta A.J., Malloy E.J., Applebaum K.M., Schwartz J., Christiani D.C., Eisen E.A.
||Reduced lung cancer mortality and exposure to synthetic fluids and biocide in the auto manufacturing industry
||Nov. 2010, Vol.36, No.6, p.499-508. Illus. 38 ref.
||Water-based soluble and synthetic metalworking fluids (MWFs) used in automotive industry may be contaminated by endotoxin from Gram-negative bacteria, a possible anti-carcinogen. This study investigated whether an inverse relationship between lung cancer and synthetic MWF and biocide persisted in an extended follow-up of autoworkers. A nested case-control analysis was performed within a retrospective cohort study of 46,399 automotive industry workers. Follow-up began in 1941 and was extended from 1985-1995. Mortality rate ratios for lung cancer were estimated in Cox regression models. Results suggest a non-linear inverse exposure-response for lung cancer mortality with increasing endotoxin exposure. Overall, the greatest reduction in mortality was observed among those with the highest exposure. Effect modification by biocides was marginally significant. The protective effect of synthetic MWFs against lung cancer mortality persisted through the extended period of follow-up, although attenuated, and was observed only among workers with co-exposure to biocide and synthetic MWFs.
||USA; biocides; cutting fluids; mortality; lung cancer; motor vehicle industry; risk factors
||bacterial toxins; long-term study; cohort study; statistical evaluation; long-term exposure
||D - Periodical articles
||Metal production and metalworking
|Broad subject area(s)
||Cancer and carcinogens
Diseases of the respiratory system (except for pneumoconiosis & similar)
Motor vehicle manufacturing industry