|Document ID (ISN)||111641|
|ISSN - Serial title
||0271-3586 - American Journal of Industrial Medicine
|Convention or series no.
||Brown S.C., Alberts R., Schoenberg M.
||Cancer incidence and mortality among workers exposed to benzidine
||Apr. 2011, Vol.54, No.4, p.300-306. 16 ref.
||A historical cohort study was conducted among 997 individuals employed at a chemical production facility to investigate whether occupational exposures to benzidine and other arylamines were associated with the increased risk of cancer. Cancers were identified from cancer registries, death certificates and medical records. Exposures were evaluated using a job-exposure matrix. Workers were categorized into exposure groups to calculate cancer-specific standardized incidence ratios (SIRs) and perform survival analyses. SIRs for cancer of the bladder (SIR 3.5), small intestine (SIR 18.4) and soft tissue including heart (SIR 11.9) were elevated among workers with the highest exposures and risk increased with increasing exposures. SIRs for several additional cancers were also elevated. Results support previous findings of increased risk of bladder cancer among individuals exposed to benzidine and other arylamines. Workers may also have been at increased risk for cancers other than cancer of the bladder.
||aromatic amines; benzidine; mortality; cancer; chemical industry; risk factors
||USA; gastrointestinal cancer; bladder tumour; exposure evaluation; cohort study; statistical evaluation; long-term exposure
||D - Periodical articles
Toxic and dangerous substances
|Broad subject area(s)
||Occupational medicine, epidemiology
||Cancer and carcinogens