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Document ID (ISN)111641
CIS number 11-0329
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 2011
Convention or series no.
Author(s) Brown S.C., Alberts R., Schoenberg M.
Title Cancer incidence and mortality among workers exposed to benzidine
Bibliographic information Apr. 2011, Vol.54, No.4, p.300-306. 16 ref.
Abstract A historical cohort study was conducted among 997 individuals employed at a chemical production facility to investigate whether occupational exposures to benzidine and other arylamines were associated with the increased risk of cancer. Cancers were identified from cancer registries, death certificates and medical records. Exposures were evaluated using a job-exposure matrix. Workers were categorized into exposure groups to calculate cancer-specific standardized incidence ratios (SIRs) and perform survival analyses. SIRs for cancer of the bladder (SIR 3.5), small intestine (SIR 18.4) and soft tissue including heart (SIR 11.9) were elevated among workers with the highest exposures and risk increased with increasing exposures. SIRs for several additional cancers were also elevated. Results support previous findings of increased risk of bladder cancer among individuals exposed to benzidine and other arylamines. Workers may also have been at increased risk for cancers other than cancer of the bladder.
Descriptors (primary) aromatic amines; benzidine; mortality; cancer; chemical industry; risk factors
Descriptors (secondary) USA; gastrointestinal cancer; bladder tumour; exposure evaluation; cohort study; statistical evaluation; long-term exposure
Document type D - Periodical articles
Subject(s) Occupational pathology
Toxic and dangerous substances
Broad subject area(s) Occupational medicine, epidemiology
Chemical safety
Browse category(ies) Cancer and carcinogens