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Document ID (ISN)111571
CIS number 11-0234
ISSN - Serial title 1745-6673 - Journal of Occupational Medicine and Toxicology
Year 2010
Convention or series no.
Author(s) Abejie B.A., Wang X., Kales S.N., Christiani D.C.
Title Patterns of pulmonary dysfunction in asbestos workers: A cross-sectional study
Bibliographic information 2010, No.5:12, 7p. Illus. 49 ref.
Internet access Patterns.pdf [in English]
Abstract Restrictive patterns of pulmonary function abnormalities associated with asbestos exposure are well described. Studies are less consistent, however, regarding the association of asbestos inhalation with airway dysfunction and obstructive impairment. This study compared pulmonary function test results between 277 chrysotile exposed workers and 177 unexposed controls, who worked at an asbestos textile products plant in China. Information on exposure and smoking were collected using a standardized questionnaire. Standardized spirometry and diffusion capacity (DCLO) methods were utilized. Chest radiographs were read based on ILO pneumoconiosis guidelines. Asbestos exposed subjects had significantly reduced forced vital capacity (FVC), one-second forced expiratory volume FEV1 and DCLO. Restricting the analysis to non-smokers, asbestos workers still had about 3% lower FEV1/FVC ratio than controls. Among exposed workers, the presence of radiographic evidence of asbestosis further lowered FVC and DLCO but not the FEV1/FVC ratio compared to asbestos exposure without radiographic asbestosis. Additionally, smoking asbestos workers had significantly lower DLCO compared to non-smoking workers. Implications of these findings are discussed.
Descriptors (primary) China; chrysotile; pulmonary function; textile industry; asbestos processing industry
Descriptors (secondary) ILO; smoking; radiological diagnosis; asbestosis; one-second forced expiratory volume; maximal expiratory flow; diffusion capacity; spirometry; chest radiography; radiological classifications; case-control study
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Asbestos
Exposure evaluation