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Document ID (ISN)111556
CIS number 11-0232
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 2010
Convention or series no.
Author(s) Beveridge R., Pintos J., Parent M.E., Asselin J., Siemiatycki J.
Title Lung cancer risk associated with occupational exposure to nickel, chromium VI, and cadmium in two population-based case-control studies in Montreal
Bibliographic information 2010, Vol.53, p.476-485. 45 ref.
Abstract Nickel, chromium VI and cadmium have been identified as lung carcinogens in highly exposed cohorts. The purpose of this study was to examine the etiological link between lung cancer and these metals in occupations that usually entail lower levels of exposure than those seen in historical cohorts. Two population-based case-control studies were conducted in Montreal, from 1979 to 1986 and from 1996 to 2001, comprising 1,598 cases and 1,965 controls. A detailed job history was obtained to evaluate lifetime occupational exposure to many agents, including nickel, chromium VI and cadmium compounds. Lung cancer odds ratios were increased only among former or non-smokers: 2.5 for nickel exposure, 2.4 for chromium VI and 4.7 for cadmium. The metals did not increase risk among smokers.
Descriptors (primary) chromium and compounds; nickel and compounds; cadmium and compounds; lung cancer; risk factors
Descriptors (secondary) Canada; smoking; exposure evaluation; case-control study
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Cancer and carcinogens
Cadmium and compounds
Nickel and compounds