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Document ID (ISN)111071
CIS number 10-0749
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2010
Convention or series no.
Author(s) Bergdahl I.A., Jonsson H., Eriksson K., Damber L., Jńrvholm B.
Title Lung cancer and exposure to quartz and diesel exhaust in Swedish iron ore miners with concurrent exposure to radon
Bibliographic information Aug. 2010, Vol.67, No.8, p.513-518. 15 ref.
Abstract Studies of underground miners have documented an increased risk of lung cancer mainly linked to radon exposure but possibly influenced by other concurrent exposures. A cohort study was carried out in 8321 iron ore miners with low exposure to radon, employed from 1923 to 1998 and followed up for lung cancer from 1958 to 2000. Historical exposures to radon, crystalline silica and diesel exhaust were assessed. Data including exposure to radon, quartz and diesel exhaust from another mine with higher exposure to radon were reanalysed. Miners had increased risk for lung cancer (SIR 1.48) based on 112 cases during 227,000 person-years. The increased risk could not be explained by exposure to radon or diesel exhaust but was associated with increasing exposure to crystalline silica: SIR 0.96, 1.45, 1.99 and 1.77 in groups with exposure to 0, 0-2, 2-5 and >5 mg years/m@3h, respectively. Reanalysis of data from the other mine indicated that quartz was a possible confounder in the analysis of the relationship between radon and lung cancer. In the highest radon exposed group, the point estimate for the RR decreased from 5.65 to 3.90 when adjusting for concurrent exposure to quartz. It is concluded that crystalline silica, a known carcinogen, probably affects lung cancer risk in iron ore miners. The main implication of the results is for interpretation of the dose-response curve for radon and lung cancer in underground iron ore miners. Since exposure to radon and quartz is often correlated, quartz exposure can be an important confounder.
Descriptors (primary) radon; silica; underground mining; lung cancer; iron ore mining; risk factors
Descriptors (secondary) Sweden; hazard evaluation; exposure evaluation; confounding factors; cohort study; male workers; long-term exposure; dose-response relationship
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Radiation
Mines and quarries
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Cancer and carcinogens
Radon
Mining and quarrying