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CISDOC database
| Document ID (ISN) | 111017 |
| CIS number |
10-0555 |
| ISSN - Serial title |
1076-2752 - Journal of Occupational and Environmental Medicine |
| Year |
2010 |
| Convention or series no. |
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| Author(s) |
Shibata E., Zhou Z., Ichihara S., Wang H., Wang Q., Li J., Zhang L, Wakai K., Takeuchi Y., Ding X., Ichihara G. |
| Title |
Dose-dependent neurologic abnormalities in workers exposed to 1-bromopropane |
| Bibliographic information |
Aug. 2010, Vol.52, No.8, p.769-777. 30 ref. |
| Abstract |
The objective of this study was to investigate the health effects of 1-bromopropane (1-BP) and its dose-dependency in 1-BP production factories in China. Data of 60 female and 26 male workers in three 1-BP factories and the same number of age-, sex- and region-matched controls were collected by means of interviews and medical examinations. The time-weighted average exposure levels of individual workers were estimated. Regression analysis on exposure level showed dose-dependent increase in the distal latency of tibial nerve, threshold for vibration sense in toes, lactate dehydrogenase, thyroid stimulating hormone, and follicle stimulating hormone in female workers. The analysis also showed dose-dependent decrease in sensory nerve conduction velocity of the sural nerve, red blood cell, and hematocrit in female workers. It is concluded that exposure to 1-BP induces dose-dependent neurotoxicity in female workers. |
| Descriptors (primary) |
China; 1-bromopropane; chemical industry; neurotoxic effects |
| Descriptors (secondary) |
enzyme inhibition; hormone secretion; vibration perception threshold; nervous function tests; exposure evaluation; case-control study; medical examinations; sex-linked differences; dose-response relationship; neurological effects |
| Document type |
D - Periodical articles |
| Subject(s) |
Occupational pathology
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| Broad subject area(s) |
Chemical safety
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| Browse category(ies) |
Chemical industry
Diseases of the nervous system
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