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CISDOC database

Document ID (ISN)111016
CIS number 10-0554
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2010
Convention or series no.
Author(s) Larson T.C., Antao V.C., Bove F.J.
Title Vermiculite worker mortality: Estimated effects of occupational exposure to Libby amphibole
Bibliographic information May 2010, Vol.52, No.5, p.555-560. 34 ref.
Abstract The objective of this study was to examine the relationship between cumulative fibre exposure (CFE) and mortality in a cohort of 1862 vermiculite workers exposed to Libby amphibole. Extended Cox regression was used to estimate the hazards associated with CFE as a time-dependent covariate of multiple-cause mortality. The Cox models for mesothelioma, asbestosis, lung cancer, and non-malignant respiratory disease were significant with rate ratios that increased monotonically with CFE. The model for deaths due to cardiovascular disease was also significant. By using a within-cohort comparison, the results demonstrate a clear exposure-response relationship between CFE and mortality from asbestos-related causes. The finding of an association between CFE and cardiovascular mortality suggests persons exposed to Libby amphibole should be monitored for this outcome.
Descriptors (primary) USA; amphibole; vermiculite; mortality; mining industry
Descriptors (secondary) mesothelioma; cardiovascular diseases; respiratory diseases; lung cancer; asbestosis; cohort study; statistical evaluation
Document type D - Periodical articles
Subject(s) Mines and quarries
Occupational pathology
Toxic and dangerous substances
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Mining and quarrying