|Document ID (ISN)||111016|
|ISSN - Serial title
||1076-2752 - Journal of Occupational and Environmental Medicine
|Convention or series no.
||Larson T.C., Antao V.C., Bove F.J.
||Vermiculite worker mortality: Estimated effects of occupational exposure to Libby amphibole
||May 2010, Vol.52, No.5, p.555-560. 34 ref.
||The objective of this study was to examine the relationship between cumulative fibre exposure (CFE) and mortality in a cohort of 1862 vermiculite workers exposed to Libby amphibole. Extended Cox regression was used to estimate the hazards associated with CFE as a time-dependent covariate of multiple-cause mortality. The Cox models for mesothelioma, asbestosis, lung cancer, and non-malignant respiratory disease were significant with rate ratios that increased monotonically with CFE. The model for deaths due to cardiovascular disease was also significant. By using a within-cohort comparison, the results demonstrate a clear exposure-response relationship between CFE and mortality from asbestos-related causes. The finding of an association between CFE and cardiovascular mortality suggests persons exposed to Libby amphibole should be monitored for this outcome.
||USA; amphibole; vermiculite; mortality; mining industry
||mesothelioma; cardiovascular diseases; respiratory diseases; lung cancer; asbestosis; cohort study; statistical evaluation
||D - Periodical articles
||Mines and quarries
Toxic and dangerous substances
|Broad subject area(s)
Occupational medicine, epidemiology
||Mining and quarrying