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CISDOC database

Document ID (ISN)111003
CIS number 10-0550
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2010
Convention or series no.
Author(s) Connor T.H., DeBord D.G., Pretty J.R., Oliver M.S., Roth T.S., Lees P.S.J., Krieg E.F., Rogers B., Escalante C.P., Toennis C.A., Clark J.C., Johnson B.C., McDiarmid M.A.
Title Evaluation of antineoplastic drug exposure of health care workers at three university-based US cancer centers
Bibliographic information Oct. 2010, Vol.52, No.10, p.1019-1027. 73 ref.
Internet access 10-0550.pdf [in English]
Abstract This cross-sectional study evaluated health care worker exposure to antineoplastic drugs. Environmental samples from pharmacy and nursing areas were examined. Descriptions of tasks involving the handling of these drugs were recorded in a diary during six weeks. Urine was analyzed for two specific drugs, and blood samples were analyzed by the comet assay. Sixty-eight exposed and 53 non-exposed workers were studied. Exposed workers recorded 10,000 drug-handling events during the 6-week period. Sixty percent of wipe samples were positive for at least one of the five drugs measured. Cyclophosphamide was most commonly detected, followed by 5-fluorouracil. Three of the 68 urine samples were positive for one drug. No genetic damage was detected in exposed workers using the comet assay. Despite following recommended safe-handling practices, workplace contamination with antineoplastic drugs in pharmacy and nursing areas continues at these locations.
Descriptors (primary) harmful substances; antineoplastic drugs; exposure evaluation; hospitals; health care personnel
Descriptors (secondary) cyclophosphamide; 5-fluorouracil; determination in urine; cross-sectional study; contamination
Document type D - Periodical articles
Subject(s) Commerce, services, offices
Broad subject area(s) Chemical safety
Browse category(ies) Health care services
Exposure evaluation