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CISDOC database
| Document ID (ISN) | 110978 |
| CIS number |
10-0546 |
| ISSN - Serial title |
0340-0131 - International Archives of Occupational and Environmental Health |
| Year |
2010 |
| Convention or series no. |
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| Author(s) |
Lovreglio P., Barbieri A., Fracasso M.E., Doria D., Drago I., Basso A., D'Errico M.N., Bartolucci G.B., Violante F.S., Soleo L. |
| Title |
Validity of new biomarkers of internal dose for use in the biological monitoring of occupational and environmental exposure to low concentrations of benzene and toluene |
| Bibliographic information |
Mar. 2010, Vol.83, No.3, p.341-356. Approx. 90 ref. |
| Abstract |
This study analyzes the validity of new, more sensitive and specific urinary biomarkers of internal dose, namely, urinary benzene for benzene and urinary toluene and S-benzylmercapturic acid (SBMA) for toluene, to assess their efficacy when compared to traditional biomarkers for biological monitoring of occupational exposure to low concentrations of these two toxic substances. Assessment was made of 41 workers occupationally exposed to benzene and toluene, 18 fuel tanker drivers and 23 filling-station attendants, together with 31 subjects with no occupational exposure to these toxic substances (controls). Exposure to airborne benzene and toluene was measured using passive personal samplers worn throughout the work shift. In urine samples collected from all subjects at the end of the workday, both the traditional and the new internal dose biomarkers of benzene and toluene were assessed, as well as creatinine so as to apply suitable adjustments. Findings confirmed the validity of trans, trans-muconic acid and S-phenylmercapturic (SPMA) acid for use in the biological monitoring of exposure to low concentrations of benzene. Urinary benzene showed comparable validity to SPMA. Urinary toluene was found to be a more specific biomarker than S-benzylmercapturic acid. Implications of these and other findings are discussed. |
| Descriptors (primary) |
benzene; toluene; exposure tests |
| Descriptors (secondary) |
breathing atmosphere; trans,trans-muconic acid; amino acids; S-phenylmercapturic acid; creatinine; metabolic process; personal sampling; determination in air; determination in urine; exposure evaluation; case-control study |
| Document type |
D - Periodical articles |
| Subject(s) |
Toxic and dangerous substances
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| Broad subject area(s) |
Chemical safety
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| Browse category(ies) |
Exposure evaluation
Aliphatic and alicyclic hydrocarbons
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