|Document ID (ISN)||110857|
|ISSN - Serial title
||0355-3140 - Scandinavian Journal of Work, Environment and Health
|Convention or series no.
||Costa G., Haus E., Stevens R.
||Shift work and cancer - Considerations on rationale, mechanisms, and epidemiology
||Mar. 2010, Vol.36, No.2, p.163-179. 185 ref.
||Shift_work_and_cancer.pdf [in English]
||This literature survey reviews the association between shift work and cancer. The mechanisms by which circadian disruption may cause malignant tumours are complex and multifactorial. The multilevel endocrine changes caused by circadian disruption with melatonin suppression through light at night lead to the oncogenic targeting of the endocrine-responsive breast in women and possibly the prostate in men. Repeated phase shifting with internal desynchronization may lead to defects in the regulation of the circadian cell cycle, thus favouring uncontrolled growth. Sleep deprivation leads to the suppression of immune surveillance that may permit the onset and growth of malignant clones. However, many epidemiological studies published lack methodological rigour and consequently do not allow for the proper assessment of the risk connected with circadian disruption.
||shift work; cancer; risk factors
||breast cancer; prostatic cancer; circadian rhythm; sleep deprivation; sex-linked differences; literature survey
||D - Periodical articles
|Broad subject area(s)
||Cancer and carcinogens
Hours of work