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CISDOC database

Document ID (ISN)110857
CIS number 10-0437
ISSN - Serial title 0355-3140 - Scandinavian Journal of Work, Environment and Health
Year 2010
Convention or series no.
Author(s) Costa G., Haus E., Stevens R.
Title Shift work and cancer - Considerations on rationale, mechanisms, and epidemiology
Bibliographic information Mar. 2010, Vol.36, No.2, p.163-179. 185 ref.
Internet access Shift_work_and_cancer.pdf [in English]
Abstract This literature survey reviews the association between shift work and cancer. The mechanisms by which circadian disruption may cause malignant tumours are complex and multifactorial. The multilevel endocrine changes caused by circadian disruption with melatonin suppression through light at night lead to the oncogenic targeting of the endocrine-responsive breast in women and possibly the prostate in men. Repeated phase shifting with internal desynchronization may lead to defects in the regulation of the circadian cell cycle, thus favouring uncontrolled growth. Sleep deprivation leads to the suppression of immune surveillance that may permit the onset and growth of malignant clones. However, many epidemiological studies published lack methodological rigour and consequently do not allow for the proper assessment of the risk connected with circadian disruption.
Descriptors (primary) shift work; cancer; risk factors
Descriptors (secondary) breast cancer; prostatic cancer; circadian rhythm; sleep deprivation; sex-linked differences; literature survey
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s) Physiology, ergonomics
Browse category(ies) Cancer and carcinogens
Hours of work