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Document ID (ISN)110768
CIS number 10-0342
ISSN - Serial title 0355-3140 - Scandinavian Journal of Work, Environment and Health
Year 2010
Convention or series no.
Title Occupational rhinosinusitis due to etoposide, an antineoplastic agent
Bibliographic information May 2010, Vol.36, No.3, p.266-267. 7 ref.
Internet access 10-0342.pdf [in English]
Abstract This article reports a rare case of an occupational hypersensitivity reaction to an antineoplastic agent in a 45-year-old nurse who developed throat irritation and chronic nasal congestion followed by sinusitis shortly after beginning work at an oncological out-patient clinic. The symptoms disappeared upon leaving the clinic two years later, but they returned when she resumed work at the oncology unit of a hospital in Denmark, handling chemotherapy on a daily basis. In vitro histamine release tests were performed against nine suspected antineoplastic agents. The patient's histamine release test against the antineoplastic agent etoposide was positive; the other test results were negative. The histamine release test against etoposide using passive sensitization was also negative. Upon leaving the oncology department, the symptoms of the nurse disappeared once again. She was given a diagnosis of rhinosinusitis.
Descriptors (primary) antineoplastic drugs; rhinitis; sinusitis; nursing personnel
Descriptors (secondary) Denmark; sensitization; symptoms; histamine release; in vitro experiments; transfer to other work; hospitals; case study
Document type D - Periodical articles
Subject(s) Commerce, services, offices
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Ionizing radiation
Health care services