| Document ID (ISN) | 110639 |
| CIS number |
10-0222 |
| ISBN(s) |
978-951-802-989-5 |
| Year |
2010 |
| Convention or series no. |
People and Work Research Reports 91
|
| Author(s) |
Holmila R. |
| Title |
Exposure-related human cancer: Molecular changes in sinonasal cancer and lung cancer, with focus on TP53 mutations |
| Bibliographic information |
Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, 00250 Helsinki, Finland, 2010. 127p. Illus. Bibl.ref. Price: EUR 23.00. Downloadable version free of charge. |
| Internet access |
http://www.tsr.fi/c/document_library/get_file?folderId=13109&name=DLFE-1701.pdf [in English]
|
| Abstract |
Carcinogenesis is driven by alterations in the sequence and function of the genes involved in many critical cellular processes. Understanding these molecular mechanisms can clarify the role and biological effects of these risk factors. In this thesis, mutations in the tumour suppressor gene, TP53, and their associations with exposure were studied in sinonasal cancer and lung cancer. Another important mechanism in cancer is inflammation, and its contribution was explored by analyzing the expression of the enzyme cyclooxygenase-2 (COX-2) in sinonasal cancer. |
| Descriptors (primary) |
wood dust; nasal cancer; lung cancer; chromosome changes |
| Descriptors (secondary) |
enzymes; DNA; inflammations; aetiology; cytogenetic studies; in vitro experiments; genetic effects; thesis |
| Document type |
E - Books, reports, proceedings |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
Occupational medicine, epidemiology
|
| Browse category(ies) |
Cancer and carcinogens
Woodworking industry
|
