|Document ID (ISN)||110625|
|ISSN - Serial title
||0340-0131 - International Archives of Occupational and Environmental Health
|Convention or series no.
||Kawai T., Ukai H., Inoue O., Maejima Y., Fukui Y., Ohashi F., Okamoto S., Takada S., Sakurai H., Ikeda M.
||Evaluation of biomarkers of occupational exposure to toluene at low levels
||Jan. 2008, Vol.81, No.3, p.253-262. Illus. 42 ref.
||The purpose of this study was to compare various biomarkers of occupational exposure to toluene (Tol) at low levels. The focus was placed on the comparison of un-metabolized toluene in urine (Tol-U) and peripheral blood (Tol-B) with hippuric acid in urine (HA-U). The study was conducted at 16 workplaces with the participation of male solvent-exposed workers. Urine and peripheral blood samples were collected at the end of the shifts. Time-weighted average exposures were monitored by diffusive sampling for toluene and other four solvents. Blood samples were subjected to the analyses for Tol-B, whereas urine samples were analyzed for HA-U and Tol-U. Solvent exposures were low. The correlation analyses of the biomarkers in urine and blood with Tol exposure showed that Tol-U and Tol-B were more closely related than HA-U. Results of receiver operator characteristic analyses were in agreement with the correlation analysis results. Tol in the end-of-shift spot urine sample appears to be the marker of choice for biological monitoring of occupational exposure to Tol at low levels.
||toluene; exposure tests; reliability
||Japan; hippuric acid; determination in air; determination in blood; determination in urine; exposure evaluation; statistical evaluation; male workers; description of technique
||D - Periodical articles
||Toxic and dangerous substances
|Broad subject area(s)
Printing, photography and photocopying industry