| Document ID (ISN) | 110625 |
| CIS number |
10-0247 |
| ISSN - Serial title |
0340-0131 - International Archives of Occupational and Environmental Health |
| Year |
2008 |
| Convention or series no. |
|
| Author(s) |
Kawai T., Ukai H., Inoue O., Maejima Y., Fukui Y., Ohashi F., Okamoto S., Takada S., Sakurai H., Ikeda M. |
| Title |
Evaluation of biomarkers of occupational exposure to toluene at low levels |
| Bibliographic information |
Jan. 2008, Vol.81, No.3, p.253-262. Illus. 42 ref. |
| Abstract |
The purpose of this study was to compare various biomarkers of occupational exposure to toluene (Tol) at low levels. The focus was placed on the comparison of un-metabolized toluene in urine (Tol-U) and peripheral blood (Tol-B) with hippuric acid in urine (HA-U). The study was conducted at 16 workplaces with the participation of male solvent-exposed workers. Urine and peripheral blood samples were collected at the end of the shifts. Time-weighted average exposures were monitored by diffusive sampling for toluene and other four solvents. Blood samples were subjected to the analyses for Tol-B, whereas urine samples were analyzed for HA-U and Tol-U. Solvent exposures were low. The correlation analyses of the biomarkers in urine and blood with Tol exposure showed that Tol-U and Tol-B were more closely related than HA-U. Results of receiver operator characteristic analyses were in agreement with the correlation analysis results. Tol in the end-of-shift spot urine sample appears to be the marker of choice for biological monitoring of occupational exposure to Tol at low levels. |
| Descriptors (primary) |
toluene; exposure tests; reliability |
| Descriptors (secondary) |
Japan; hippuric acid; determination in air; determination in blood; determination in urine; exposure evaluation; statistical evaluation; male workers; description of technique |
| Document type |
D - Periodical articles |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Air pollution
Biological monitoring
Printing, photography and photocopying industry
|
