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CISDOC database

Document ID (ISN)110252
CIS number 09-1297
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 2009
Convention or series no.
Author(s) Romeo L., Catalani S., Pasini F., Bergonzi R., Perbellini L., Apostoli P.
Title Xenobiotic action on steroid hormone synthesis and sulfonation - The example of lead and polychlorinated biphenyls
Bibliographic information Apr. 2009, Vol.82, No.5, p.557-564. Illus. 31 ref.
Abstract This study investigated the metabolism of steroid hormones to determine whether and how xenobiotics such as lead (Pb) and polychlorinated biphenyls (PCBs) interfere with steroid hormone biotransformation in humans. Three groups of subjects were tested for urinary steroids: 14 workers exposed to lead, 15 workers exposed to PCBs and an unexposed control group of 25 subjects. Findings suggest PCBs and Pb act on steroid hormone metabolism with different effects and only partially using the same hormone pathways.
Descriptors (primary) polychlorinated biphenyls; lead and compounds; toxic substances; metabolic disturbances; steroids
Descriptors (secondary) hormones; determination in urine; case-control study
Document type D - Periodical articles
Country / State or ProvinceItaly
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Endocrine diseases
Halogenated hydrocarbons
Lead and compounds
Inorganic substances