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Document ID (ISN)110113
CIS number 09-1112
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2009
Convention or series no.
Author(s) Wang Y., Duan H., Dai Y., Bin P., Cheng J., Pan Z., Huang C., Leng S., Chen W., Zheng Y.
Title Uridine diphosphoglucuronosyltransferase 1A7 gene polymorphism and susceptibility to chromosomal damage among polycyclic aromatic hydrocarbons exposed workers
Bibliographic information June 2009, Vol.51, No.6, p.682-689. Illus. 56 ref.
Abstract The aim of this study was to explore the relationship between uridine diphosphoglucuronosyltransferase 1A7 (UGT1A7) gene polymorphisms and susceptibility to chromosomal damage among polycyclic aromatic hydrocarbons (PAH)-exposed workers. Blood and urine samples of 140 PAH-exposed workers and 66 non-PAH-exposed workers were collected. The polymorphisms of UGT1A7, cytokinesis-block micronucleus (CBMN) and 1-hydroxypyrene were analyzed. Findings are discussed. It is concluded that polymorphisms of UGT1A7 gene may alter the severity of PAH-induced chromosomal damage among the exposed workers.
Descriptors (primary) aromatic hydrocarbons; chromosome changes; polycyclic hydrocarbons; DNA
Descriptors (secondary) case-control study; determination in urine; determination in blood; 1-hydroxypyrene
Document type D - Periodical articles
Country / State or ProvinceChina
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Polycyclic hydrocarbons
Aromatic hydrocarbons
Genetic factors in reaction to exposures