|Document ID (ISN)||110092|
|ISSN - Serial title
||1076-2752 - Journal of Occupational and Environmental Medicine
|Convention or series no.
||Rajan P., Kelsey K.T., Schwartz J.D., Bellinger D.C., Weuve J., Spiro A., Sparrow D., Smith T.J., Nie H., Weisskopf M.G., Hu H., Wright R.O.
||Interaction of the δ-aminolevulinic acid dehydratase polymorphism and lead burden on cognitive function: The VA normative ageing study
||Sep 2008, Vol.50, No.9, p.1053-1061. 36 ref.
||09-1111.pdf [in English]
||This study evaluated the modifying influence of a δ-aminolevulinic acid dehydratase (ALAD) gene polymorphism on the relation between lead burden and cognition among older men. Information on ALAD genotype, lead measurements, potential confounders and cognitive testing was collected from 982 veterans. Data were analyzed using multiple linear regression models. With higher levels of tibia lead, ALAD 1-2/2-2 carriers exhibited worse performance on a spatial copying test in comparison with ALAD 1-1 carriers. However, there was no consistent pattern of an ALAD genotype-lead interaction for the other tests.
||cognitive performance; lead and compounds; genetic effects; ageing; ALAD
||older workers; enzymes; determination in bones; statistical evaluation; defence services
||D - Periodical articles
|Country / State or Province||USA|
|Broad subject area(s)
||Antifertility and prenatal effects
Lead and compounds
Genetic factors in reaction to exposures