ILO Home
Go to the home page
Site map | Contact us Franšais | Espa˝ol

CISDOC database

Document ID (ISN)110092
CIS number 09-1111
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2008
Convention or series no.
Author(s) Rajan P., Kelsey K.T., Schwartz J.D., Bellinger D.C., Weuve J., Spiro A., Sparrow D., Smith T.J., Nie H., Weisskopf M.G., Hu H., Wright R.O.
Title Interaction of the δ-aminolevulinic acid dehydratase polymorphism and lead burden on cognitive function: The VA normative ageing study
Bibliographic information Sep 2008, Vol.50, No.9, p.1053-1061. 36 ref.
Abstract This study evaluated the modifying influence of a δ-aminolevulinic acid dehydratase (ALAD) gene polymorphism on the relation between lead burden and cognition among older men. Information on ALAD genotype, lead measurements, potential confounders and cognitive testing was collected from 982 veterans. Data were analyzed using multiple linear regression models. With higher levels of tibia lead, ALAD 1-2/2-2 carriers exhibited worse performance on a spatial copying test in comparison with ALAD 1-1 carriers. However, there was no consistent pattern of an ALAD genotype-lead interaction for the other tests.
Descriptors (primary) cognitive performance; lead and compounds; genetic effects; ageing; ALAD
Descriptors (secondary) older workers; enzymes; determination in bones; statistical evaluation; defence services
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Older workers
Lead and compounds
Inorganic substances
Genetic factors in reaction to exposures