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Document ID (ISN)110089
CIS number 09-1129
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2008
Convention or series no.
Author(s) J÷nsson L.S., Littorin M., Axmon A., J÷nsson B.A.G., Broberg K.
Title Lung function in relation to 2-thiothiazolidine-4-carboxylic acid and genetic effect modification among rubber workers in Sweden
Bibliographic information Sep 2008, Vol.50, No.9, p.1006-1012. 43 ref.
Abstract The objective of this study was to evaluate the risk of impaired lung function among Swedish rubber workers. Included in the study were 159 rubber exposed and 118 unexposed controls. Urinary levels of 2-thiothiazolidine-4-carboxylic acid (a marker of carbon disulfide and vulcanization fumes) were assessed by liquid chromatography coupled with mass spectrometry. Polymorphisms in glutathione-related genes were analyzed by Taqman-based allelic discrimination and conventional polymerase chain reaction. There was an association between increasing levels of 2-thiothiazolidine-4-carboxylic acid and impaired lung function among exposed workers. The association was modified by glutathione S-transferase alpha 1 (GSTA1)-52 and GSTP1-114. Implications of these findings are discussed.
Descriptors (primary) rubber industry; Sweden; 2-thiothiazolidine-4-carboxylic acid; respiratory impairment; genetic effects; risk factors; pulmonary function
Descriptors (secondary) mass spectrometry; carbon disulfide; glutathione; glutathione transferase; case-control study; high-pressure liquid chromatography; dose-response relationship; sampling and analysis; exposure tests; determination in urine; vulcanizing agents; spirometry
Document type D - Periodical articles
Country / State or ProvinceSweden
Subject(s) Chemicals, plastics and rubber
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Diseases of the respiratory system (except for pneumoconiosis & similar)
Heterocyclic compounds
Rubber industry
Genetic factors in reaction to exposures