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Document ID (ISN)110047
CIS number 09-1127
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 2009
Convention or series no.
Author(s) van Amelsvoort L.G.P.M., Slangen J.J.M., Tsai S.P., de Jong G., Kant I.
Title Cancer mortality in workers exposed to dieldrin and aldrin: Over 50 years of follow up
Bibliographic information Jan. 2009, Vol.82, No.2, p.217-225. 29 ref.
Abstract Dieldrin and aldrin, two pesticides widely used until the 1970s, have been under suspicion of being carcinogenic. In this study, mortality was assessed in a cohort of 570 production employees exposed to these pesticides from 1954 to 1970 followed for cause-specific mortality until 2006. The total intake of dieldrin was estimated for each individual subject in the cohort based on blood samples taken during the exposure period. A total of 226 workers had died before 2006 compared with an expected number of 327.3, giving a standardized mortality ratio (SMR) of 69.0. Overall cancer mortality was also significantly lower than expected (SMR 76.4). Furthermore, none of the specific cancer sites showed a significant excess mortality and no association between exposure level and cancer mortality was found.
Descriptors (primary) aldrin; dieldrin; risk factors; cancer; mortality
Descriptors (secondary) carcinogens; pesticides; exposure evaluation; determination in blood; long-term study; statistical evaluation; cohort study
Document type D - Periodical articles
Country / State or ProvinceNetherlands; USA
Subject(s) Chemicals, plastics and rubber
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Halogenated hydrocarbons