Document ID (ISN) | 110047 |
CIS number |
09-1127 |
ISSN - Serial title |
0340-0131 - International Archives of Occupational and Environmental Health |
Year |
2009 |
Convention or series no. |
|
Author(s) |
van Amelsvoort L.G.P.M., Slangen J.J.M., Tsai S.P., de Jong G., Kant I. |
Title |
Cancer mortality in workers exposed to dieldrin and aldrin: Over 50 years of follow up |
Bibliographic information |
Jan. 2009, Vol.82, No.2, p.217-225. 29 ref. |
Abstract |
Dieldrin and aldrin, two pesticides widely used until the 1970s, have been under suspicion of being carcinogenic. In this study, mortality was assessed in a cohort of 570 production employees exposed to these pesticides from 1954 to 1970 followed for cause-specific mortality until 2006. The total intake of dieldrin was estimated for each individual subject in the cohort based on blood samples taken during the exposure period. A total of 226 workers had died before 2006 compared with an expected number of 327.3, giving a standardized mortality ratio (SMR) of 69.0. Overall cancer mortality was also significantly lower than expected (SMR 76.4). Furthermore, none of the specific cancer sites showed a significant excess mortality and no association between exposure level and cancer mortality was found. |
Descriptors (primary) |
aldrin; dieldrin; risk factors; cancer; mortality |
Descriptors (secondary) |
carcinogens; pesticides; exposure evaluation; determination in blood; long-term study; statistical evaluation; cohort study |
Document type |
D - Periodical articles |
Country / State or Province | Netherlands; USA |
Subject(s) |
Chemicals, plastics and rubber
|
Broad subject area(s) |
Chemical safety Occupational medicine, epidemiology
|
Browse category(ies) |
Halogenated hydrocarbons
|