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Document ID (ISN)109903
CIS number 09-815
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2009
Convention or series no.
Author(s) Cox-Ganser J.M., Burchfiel C.M., Fekedulegn D., Andrew M.E., Ducatman B.S.
Title Silicosis in lymph nodes: The canary in the miner?
Bibliographic information Feb. 2009, Vol.51, No.2, p.164-169. Illus. 11 ref.
Abstract The objective of this study was to investigate evidence that lymph node silicosis can precede parenchymal silicosis. The study population was comprised of 264 deceased male uranium miners in former East Germany for whom pathologists agreed on the presence or absence of silicosis in lymph nodes and lung parenchyma, and for who work histories and silica exposure estimates were available. Twenty percent of the miners had lymph node silicosis only, 4% had parenchymal silicosis only and 39% had both. Silica exposure was lower for miners with lymph node silicosis only than for those with both lymph node and parenchymal silicosis. Lymph node silicosis was associated with parenchymal silicosis after adjustment for silica exposure. Findings are consistent with silicosis potentially occurring in lymph nodes before the parenchyma. Lymph node damage could impair silica clearance and increase the risk for parenchymal silicosis.
Descriptors (primary) lymph nodes; male workers; uranium mining; silicosis; Germany
Descriptors (secondary) silica; histopathology; exposure evaluation; bronchopulmonary clearance
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Mines and quarries
Broad subject area(s) Industries and occupations
Occupational medicine, epidemiology
Browse category(ies) Pneumoconioses
Mining and quarrying