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Document ID (ISN)109889
CIS number 09-816
ISSN - Serial title 0339-6517 - Documents pour le médecin du travail
Year 2009
Convention or series no. DMT118TF180
Author(s) Bourgkard E., Wild P., Courcot B., Diss M., Ettlinger J., Goutet P., Hemon D., Marquis N., Mur J.M., Rigal C., Rohn-Janssens M.P., Moulin J.J.
Title Lung cancer mortality and iron oxide exposure in a French steel-producing factory
Original title Mortalité par cancer du poumon et exposition aux oxydes de fer dans une usine sidérurgique française [in French]
Bibliographic information 2nd Quarter 2009, No.118, p.209-220. 32 ref.
Internet access http://www.dmt-prevention.fr/inrs-pub/inrs01.nsf/IntranetObject-accesParReference/TF%20180/$File/TF180.pdf [in French]
Abstract The objective of this study was to highlight a possible relationship between exposure to iron oxides and the risk of lung cancer among workers of a French steel mill producing carbon steel. A historical cohort comprising all workers having ever worked for at least a year between 1959 and 1997 was constituted. Causes of death were determined from death certificates, while occupational exposures were evaluated with the help of a plant-specific job-exposure matrix developed by a panel of eight experts and validated by atmospheric sampling. The cohort consisted of 16,742 men and 959 women, followed-up for mortality from 1968 to 1998. Standardised mortality ratios (SMRs) were computed using local death rates. Poisson regressions were used to estimate the relative risks (RRs) for occupational exposures, after adjustment for potential confounding factors. Among men, mortality was lower than expected for lung cancer compared to the local population (SMR 0.89) and higher than expected compared to the French population (SMR 1.30). A significant bladder cancer excess was observed among workers exposed to oil mist (RR 2.44). Other findings are discussed.
Descriptors (primary) iron oxide; France; steelworks; lung cancer; mortality
Descriptors (secondary) oil mist; bladder tumour; cohort study; determination in air; job-exposure relation; statistical evaluation; risk factors
Document type D - Periodical articles
Country / State or ProvinceFrance
Subject(s) Metal production and metalworking
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Iron and steel industry
Iron and compounds
Inorganic substances