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CISDOC database
| Document ID (ISN) | 109877 |
| CIS number |
09-886 |
| ISSN - Serial title |
0105-1873 - Contact Dermatitis |
| Year |
2009 |
| Convention or series no. |
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| Author(s) |
Lessmann H., Uter W., Schnuch A., Geier J. |
| Title |
Skin sensitizing properties of the ethanolamines mono-, di-, and triethanolamine. Data analysis of a multicentre surveillance network (IVDK*) and review of the literature |
| Bibliographic information |
May 2009, Vol.60, No.5, p.243-255. 83 ref. |
| Abstract |
Numerous publications address the skin sensitizing potential of the short chain alkanolamines triethanolamine (TEA), diethanolamine (DEA), monoethanolamine (MEA), which are not skin sensitizing according to animal studies. In this work, data of the literature on MEA, DEA and TEA as well as data of a multicentre surveillance network were analyzed. For TEA, patch test data of 85,098 patients were examined. Altogether, 323 patients (0.4%) tested positive. The profile of patch test reactions indicates a slightly irritant potential rather than a true allergic response in many cases. The risk of sensitization to TEA seems to be very low. For MEA and DEA, patch tests in 9602 and 8791 patients, respectively revealed a prevalence of contact allergy of 3.8% and 1.8%. Chronic damage to the skin barrier, the alkalinity of ethanolamines and other cofactors may contribute to a notable sensitization risk. |
| Descriptors (primary) |
ethanolamine; diethanolamine; sensitization; skin allergies; triethanolamine |
| Descriptors (secondary) |
skin tests; literature survey |
| Document type |
D - Periodical articles |
| Country / State or Province | Germany |
| Subject(s) |
Occupational pathology
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| Broad subject area(s) |
Chemical safety
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| Browse category(ies) |
Allergies
Skin diseases
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