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CISDOC database
| Document ID (ISN) | 109743 |
| CIS number |
09-645 |
| ISSN - Serial title |
0271-3586 - American Journal of Industrial Medicine |
| Year |
2008 |
| Convention or series no. |
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| Author(s) |
Wu F., Xia Z., Qu Y., Tang Y., Cao D., Sun P., Christiani D.C. |
| Title |
Genetic polymorphisms of IL-1A, IL-1B, IL-1RN, NFKB1, FAS, and FASL, and risk of silicosis in a Chinese occupational population |
| Bibliographic information |
Nov. 2008, Vol.51, No.11, p.843-851. 26 ref. |
| Abstract |
To test whether polymorphisms in IL-1, NF-KB, FAS and FASL genes are associated with risk of silicosis, a case-control study was conducted with 183 silicosis patients and 111 silica-exposed miners who were frequency-matched by age, dust exposure duration, work location, and type of work. Genotype analysis was performed on genomic DNA, using a PCR-RFLP assay. Findings are discussed. |
| Descriptors (primary) |
China; silicosis; mining industry; risk factors; genetic effects |
| Descriptors (secondary) |
DNA; case-control study; silica |
| Document type |
D - Periodical articles |
| Country / State or Province | China; USA |
| Subject(s) |
Occupational pathology
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| Broad subject area(s) |
Chemical safety
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| Browse category(ies) |
Mining and quarrying
Genetic factors in reaction to exposures
Pneumoconioses
Antifertility and prenatal effects
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