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CISDOC database

Document ID (ISN)109743
CIS number 09-645
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 2008
Convention or series no.
Author(s) Wu F., Xia Z., Qu Y., Tang Y., Cao D., Sun P., Christiani D.C.
Title Genetic polymorphisms of IL-1A, IL-1B, IL-1RN, NFKB1, FAS, and FASL, and risk of silicosis in a Chinese occupational population
Bibliographic information Nov. 2008, Vol.51, No.11, p.843-851. 26 ref.
Abstract To test whether polymorphisms in IL-1, NF-KB, FAS and FASL genes are associated with risk of silicosis, a case-control study was conducted with 183 silicosis patients and 111 silica-exposed miners who were frequency-matched by age, dust exposure duration, work location, and type of work. Genotype analysis was performed on genomic DNA, using a PCR-RFLP assay. Findings are discussed.
Descriptors (primary) China; silicosis; mining industry; risk factors; genetic effects
Descriptors (secondary) DNA; case-control study; silica
Document type D - Periodical articles
Country / State or ProvinceChina; USA
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Mining and quarrying
Genetic factors in reaction to exposures
Pneumoconioses