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Document ID (ISN)109741
CIS number 09-644
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 2008
Convention or series no.
Author(s) Vaktskjold A., Talykova L.V., Chashchin V.P., Odland J.Í., Nieboer E.
Title Maternal nickel exposure and congenital musculoskeletal defects
Bibliographic information Nov. 2008, Vol.51, No.11, p.825-833. 47 ref.
Abstract The objective of this study was to investigate whether women occupationally exposed to nickel in the nickel and copper refineries in the Kola region of Russia in early pregnancy were at elevated risk of delivering a newborn with a malformation or deformation of the musculoskeletal system. Data were obtained from the Kola Birth Register. Each record was assigned a categorical nickel exposure rating according to the occupation the delivering woman had at the time of becoming pregnant. Based on 22,965 births, 304 infants (13.3/1,000 births) were diagnosed with musculoskeletal defects at birth, especially for feet deformities. The incidence was high, but unrelated to maternal exposure to nickel. Implications of these findings are discussed.
Descriptors (primary) Russian Federation; nickel and compounds; nickel; musculoskeletal diseases; smelting plants; women; expectant mothers; neighbourhood populations; teratogenic effects
Descriptors (secondary) parental exposure; hazard evaluation; frequency rates; health service records; exposure evaluation
Document type D - Periodical articles
Country / State or ProvinceCanada; Denmark; Norway; Russian Federation; Sweden; USA
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the musculoskeletal system
Antifertility and prenatal effects
Smelting and refining operations
Inorganic substances
Nickel and compounds
Genetic factors in reaction to exposures