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CISDOC database

Document ID (ISN)109734
CIS number 09-563
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 2008
Convention or series no.
Author(s) Ates I., Suzen H.S., Yucesoy B., Tekin I.O., Karakaya A.
Title Association of cytokine gene polymorphisms in CWP and its severity in Turkish coal workers
Bibliographic information Oct. 2008, Vol.51, No.10, p.741-747. 49 ref.
Abstract To determine the cytokine gene profiles of Turkish coal miners, a genotyping analysis was performed to investigate the polymorphisms pro-inflammatory (TNFA, IL1A, IL1B, and IL6) and anti-inflammatory cytokines (IL-1RN and TGFB1) related to coal workers' pneumoconiosis (CWP). An additional goal was to observe whether these cytokine gene polymorphisms influence the development risk and severity of CWP. Genotyping was carried out by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Findings suggest that the TNFA (-238) variant may be a risk factor in both the development and severity of CWP, while the TNFA (-308) variant seems to be important only in disease severity. On the other hand, IL6 variant may have a protective effect on the development and disease severity.
Descriptors (primary) Turkey; genetic effects; coalworkers pneumoconiosis; coal mining; risk factors
Descriptors (secondary) interleukins; severity rates; inflammations; DNA
Document type D - Periodical articles
Country / State or ProvinceTurkey
Subject(s) Mines and quarries
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Antifertility and prenatal effects
Mining and quarrying
Genetic factors in reaction to exposures
Pneumoconioses