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CISDOC database

Document ID (ISN)109307
CIS number 09-319
ISSN - Serial title 0962-7480 - Occupational Medicine
Year 2007
Convention or series no.
Author(s) Jones S.R., Atkin P., Holroyd C., Lutman E., Vives i Batlle J., Wakeford R., Walker P.
Title Lung cancer mortality at a UK tin smelter
Bibliographic information June 2007, Vol.57, No.4, p.238-245. Illus. 45 ref.
Abstract The aim of this study was to investigate the relationship between lung cancer mortality and quantitative measures of exposure in a tin smelter. Using available records of occupational hygiene measurements, exposure matrices for arsenic, cadmium, lead, antimony and polonium-210, covering the main process areas of the smelter, were established as well as work histories from personnel record cards for the previously defined cohort of 1462 male employees. Three different methods of extrapolation were used to assess exposures prior to 1972 when no measurement results were available. Lung cancer mortality was examined in relation to cumulative inhalation exposure by Poisson regression analysis. No significant associations could be found between lung cancer mortality and simple cumulative exposure to any of the substances studied. When cumulative exposures were weighted according to time since exposure and attained age, significant associations were found between lung cancer mortality and exposures to arsenic, lead and antimony. Other findings are discussed.
Descriptors (primary) antimony and compounds; United Kingdom; arsenic and compounds; smelting plants; mortality; lung cancer; lead and compounds
Descriptors (secondary) cohort study; statistical evaluation; dose-response relationship; length of exposure
Document type D - Periodical articles
Country / State or ProvinceUnited Kingdom
Subject(s) Metal production and metalworking
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Inorganic substances
Arsenic and compounds
Diseases of the respiratory system (except for pneumoconiosis & similar)
Smelting and refining operations
Lead and compounds