| Document ID (ISN) | 109299 |
| CIS number |
09-394 |
| ISSN - Serial title |
1232-1087 - International Journal of Occupational Medicine and Environmental Health |
| Year |
2007 |
| Convention or series no. |
|
| Author(s) |
Szyman£ka-Chabowska A., Antonowicz-Juchniewicz J,, Andrzejak R. |
| Title |
The concentration of selected cancer markers (TPA, TPS, CYFRA 21-1, CEA) in workers occupationally exposed to arsenic (As) and some heavy metals (Pb, Cd) during a two-year observation study |
| Bibliographic information |
3rd quarter 2007, Vol.20, No.3, p.229-239. Illus. 30 ref. |
| Abstract |
Molecular epidemiology studies have lately been focused on occupational cancer associated with exposure to chemical carcinogens in the work environment. A two-year observation study was designed to investigate the relationship between arsenic, lead and cadmium concentrations and the levels of cancer markers: TPA (tissue polypeptide antigen), TPS (tissue polypeptide specific antigen), CYFRA 21-1 and CEA (carcinoembryonic antigen) in 69 male workers occupationally exposed to As and Pb, and environmentally exposed to Cd via tobacco smoking. Significant correlations were found between CEA and blood Cd concentrations or between CEA and the duration of work under exposure. All the metals examined were found to have an influence on the concentration of cancer markers, except for CYFRA 21-1. Other findings are discussed. |
| Descriptors (primary) |
cadmium and compounds; carcinogens; smelting plants; lead and compounds; arsenic and compounds |
| Descriptors (secondary) |
Poland; antigens; determination in urine; long-term study; determination in blood; exposure evaluation |
| Document type |
D - Periodical articles |
| Country / State or Province | Poland |
| Subject(s) |
Metal production and metalworking
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Inorganic substances
Arsenic and compounds
Smelting and refining operations
Lead and compounds
Cadmium and compounds
|
