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Document ID (ISN)109299
CIS number 09-394
ISSN - Serial title 1232-1087 - International Journal of Occupational Medicine and Environmental Health
Year 2007
Convention or series no.
Author(s) Szymanúka-Chabowska A., Antonowicz-Juchniewicz J,, Andrzejak R.
Title The concentration of selected cancer markers (TPA, TPS, CYFRA 21-1, CEA) in workers occupationally exposed to arsenic (As) and some heavy metals (Pb, Cd) during a two-year observation study
Bibliographic information 3rd quarter 2007, Vol.20, No.3, p.229-239. Illus. 30 ref.
Abstract Molecular epidemiology studies have lately been focused on occupational cancer associated with exposure to chemical carcinogens in the work environment. A two-year observation study was designed to investigate the relationship between arsenic, lead and cadmium concentrations and the levels of cancer markers: TPA (tissue polypeptide antigen), TPS (tissue polypeptide specific antigen), CYFRA 21-1 and CEA (carcinoembryonic antigen) in 69 male workers occupationally exposed to As and Pb, and environmentally exposed to Cd via tobacco smoking. Significant correlations were found between CEA and blood Cd concentrations or between CEA and the duration of work under exposure. All the metals examined were found to have an influence on the concentration of cancer markers, except for CYFRA 21-1. Other findings are discussed.
Descriptors (primary) cadmium and compounds; carcinogens; smelting plants; lead and compounds; arsenic and compounds
Descriptors (secondary) Poland; antigens; determination in urine; long-term study; determination in blood; exposure evaluation
Document type D - Periodical articles
Country / State or ProvincePoland
Subject(s) Metal production and metalworking
Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Inorganic substances
Arsenic and compounds
Smelting and refining operations
Lead and compounds
Cadmium and compounds