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Document ID (ISN)109298
CIS number 09-393
ISSN - Serial title 1351-0711 - Occupational and Environmental Medicine
Year 2008
Convention or series no.
Author(s) Sikkeland L.I.B., Skogstad M., ěvsteb° R., Brusletto B., Haug K.B.F., Kongerud J., Eduard W., Kierulf P.
Title Circulating lipopolysaccharides in the blood from "bioprotein" production workers
Bibliographic information Mar. 2008, Vol.65, No.3, p.211-214. Illus. 13 ref.
Abstract Workers producing bacterial single-cell protein (bioprotein) are exposed to organic dust containing high levels of endoxins (lipopolysaccharides, LPS). Workers in this industry have complained of episodes of fever, fatigue, chest tightness, skin dryness and rubor. The aim of this study was to quantify LPS and inflammatory mediators in plasma in eight non-smoking production and eight non-smoking, non-exposed controls. Airborne and plasma endotoxin concentrations were measured, as well as plasma high sensitivity C-reactive protein and different cytokines, chemokines and metalloproteinases. The workers who did not use personal respiratory protection were exposed to varying airborne levels of endotoxin (75-15,000 EU/m3). The level of plasma LPS was significantly elevated among the workers compared to the non-exposed controls. The workers also had increased levels of several inflammatory cytokines.
Descriptors (primary) bacterial toxins; biological hazards; exposure evaluation; inhalation
Descriptors (secondary) proteins; polysaccharides; interleukins; determination in blood; respirators; determination in air; case-control study
Document type D - Periodical articles
Country / State or ProvinceNorway
Subject(s) Toxic and dangerous substances
Broad subject area(s) Biological hazards
Chemical safety
Browse category(ies) Biological hazards
Exposure evaluation