| Document ID (ISN) | 109227 |
| CIS number |
09-158 |
| ISSN - Serial title |
1076-2752 - Journal of Occupational and Environmental Medicine |
| Year |
2008 |
| Convention or series no. |
|
| Author(s) |
Nuernberg A.M., Boyce P.D., Cavallari J.M., Fang S.C., Eisen E.A., Christiani D.C. |
| Title |
Urinary 8-isoprostane and 8-OHdG concentrations in boilermakers with welding exposure |
| Bibliographic information |
Feb. 2008, Vol.50, No.2, p.182-189. Illus. 35 ref. |
| Abstract |
To investigate the association of exposure to fine particulate matter (PM 2.5) with DNA damage and oxidative stress in boilermakers exposed to welding fumes, 41 workers were monitored over 24 hours during which baseline, post-shift, bedtime, and next morning urine samples were collected. Blood samples were also collected pre-shift and the following morning. Twenty-two unexposed workers participated as controls. Linear regression was used to model changes in u-8-isoprostane and u-8-OHdG. Acute welding fume exposure was found to be associated with a post-shift blunting of systemic inflammation, as measured by 8-isoprostane, in chronically exposed workers. The level of oxidative DNA damage as measured by 8-OHdG was less clear. |
| Descriptors (primary) |
DNA; respirable dust; welding and cutting; boilermaking; exposure tests; welding fumes |
| Descriptors (secondary) |
exposure evaluation; case-control study; determination in urine; determination in blood; statistical evaluation |
| Document type |
D - Periodical articles |
| Country / State or Province | USA |
| Subject(s) |
Metal production and metalworking
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Metalworking industry
Biological monitoring
Welding and cutting
|
