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CISDOC database

Document ID (ISN)109181
CIS number 09-145
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 2008
Convention or series no.
Author(s) Duhayon S., Hoet P., Van Maele-Fabry G., Lison D.
Title Carcinogenic potential of formaldehyde in occupational settings: A critical assessment and possible impact on occupational exposure levels
Bibliographic information May 2008, Vol.81, No.6, p.695-710. Illus. 54 ref.
Abstract This literature survey reviewed epidemiological studies investigating the association between occupational exposure to formaldehyde and nasopharyngeal cancer (NPC) risk having led to a change in the classification of formaldehyde by the International Agency for Research on Cancer (IARC) in 2004, as well as studies published thereafter, with the objective to examine whether occupational exposure levels for formaldehyde should be changed. Human studies concerning the carcinogenicity of formaldehyde are not conclusive. Experimental data indicate that in rats, the carcinogenic activity of formaldehyde is associated with cytotoxic mechanisms. Current exposure limits are sufficient for protecting from these effects and should therefore be sufficient to protect from potential carcinogenic effects, if any in humans.
Descriptors (primary) threshold limit values; formaldehyde; carcinogenic effects; cancer; risk factors; carcinogens
Descriptors (secondary) literature survey; IARC; epidemiology; reliability; assessment of knowledge; animal experiments; cytotoxic effects; classification; limitation of exposure
Document type D - Periodical articles
Country / State or ProvinceBelgium
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Occupational medicine, epidemiology
Browse category(ies) Aldehydes
Occupational exposure limits