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Document ID (ISN)109100
CIS number 09-127
ISSN - Serial title 0019-8366 - Industrial Health
Year 2008
Convention or series no.
Author(s) Ohbayashi H., Saito M., Senoh H., Umeda Y., Aiso S., Yamazaki K., Nagano K., Yamamoto S., Fukushima S.
Title Occurrence of two different types of glutathione S-transferase placental form-positive hepatocytes after a single administration of 2,3,7,8-tetrabromodibenzo-p-dioxin in rats
Bibliographic information May 2008, Vol.46, No.3, p.281-288. Illus. 40 ref.
Abstract Occurrence of glutathione S-transferase placental form (GST-P)-positive hepatocytes was examined, using 15 Wistar rats of both sexes each orally administered 2,3,7,8-tetrabromo-dibenzo-p-dioxin (TBDD) by gavage at a single dose of 0, 10, 30, 100 or 300 Á/kg body weight. Liver tissues were stained with anti-GST-P antibody. The characteristics of the two types of GST-P-positive hepatocytes which were found in the TBDD-dosed rat are discussed.
Descriptors (primary) liver; glutathione transferase; tetrabromodibenzodioxin
Descriptors (secondary) antibodies; microscopic determination; animal experiments
Document type D - Periodical articles
Country / State or ProvinceJapan
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Heterocyclic compounds