|Document ID (ISN)||108994|
|ISSN - Serial title
||0271-3586 - American Journal of Industrial Medicine
|Convention or series no.
||Ates I., Suzen H.S., Yucesoy B., Tekin I.O., Karakaya A.
||Association of cytokine gene polymorphisms in CWP and its severity in Turkish coal workers
||Oct. 2008, Vol.51, No.10, p.741-747. 49 ref.
||Cytokines are believed to play a key role in inflammatory mechanisms that result in several diseases such as coal workers' pneumoconiosis (CWP). To determine the cytokine gene profiles of Turkish coal miners, a genotyping analysis was performed to investigate the polymorphisms of CWP-related pro-inflammatory and anti-inflammatory cytokines. Genotyping was carried out by the polymerase chain reaction technique, coupled with fragment length polymorphism restriction. It was found that the TNFA (-238) variant was a risk factor in both the development and severity of CWP, while the TNFA (-308) variant was important only in disease severity. On the other hand, IL6 variant may have a protective effect on both development and severity.
||Turkey; genetic effects; coalworkers pneumoconiosis; coal mining; risk factors
||interleukins; severity rates; inflammations; DNA
||D - Periodical articles
|Country / State or Province||Turkey|
||Mines and quarries
|Broad subject area(s)
||Occupational medicine, epidemiology
Industries and occupations
||Antifertility and prenatal effects
Mining and quarrying
Genetic factors in reaction to exposures