|Document ID (ISN)||108859|
|ISSN - Serial title
||0339-6517 - Documents pour le médecin du travail
|Convention or series no.
||Jacob S., Héry M., Stengel B.
||Exposure to organic solvents - Risk of evolution of chronic renal diseases towards terminal renal insufficiency
||Exposition aux solvants organiques - Risque de progression des maladies rénales chroniques vers l'insuffisance rénale terminale [in French]|
||June 2008, No.114, p.233-241. Illus. 33 ref.
||http://www.dmt-prevention.fr/inrs-pub/inrs01.nsf/IntranetObject-accesParReference/TF%20170/$File/TF170.pdf [in French]
||This article describes a retrospective cohort study involving 338 patients suffering from glomerular nephropathies for which biopsies were performed between 1994 and 2001, and who were followed up until 2004. Their exposures to solvents were evaluated by industrial hygienists on the basis of interview data. Terminal renal insufficiency (TRI) was defined either as the patient requiring dialysis or a glomerular filtration rate of less than 15mL/min per 1.73m2. The relative risks of TRI associated with solvents were estimated using Cox regression models. It was found that high solvent exposure levels were associated with twofold to fourfold higher TRI risks. Products or chemicals giving rise to the greatest risks were printing inks, fuels, toluene, xylene, petroleum products and acetone. The most exposed workers were mechanics and fitters, plumbers and welders. These findings highlight the importance of screening for glomerular diseases and increased medical supervision of workers exposed to solvents in occupational settings.
||chronic diseases; risk factors; organic solvents; renal diseases
||petroleum products; dialysis; acetone; toluene; occupation disease relation; printing inks; renal insufficiency; fuels; diagnosis; xylene; hazard evaluation; exposure evaluation; cohort study; biopsy; job-exposure relation; statistical evaluation; medical supervision; France
||D - Periodical articles
|Country / State or Province||France|
||Toxic and dangerous substances
|Broad subject area(s)
Occupational medicine, epidemiology
||Diseases of the kidney and the urinary system