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Document ID (ISN)108826
CIS number 08-1399
ISBN(s) 978-2-89631-251-1
Year 2008
Convention or series no. Etudes et Recherches R-556
Author(s) Fournier M., Bernier J., Brousseau P., Cyr D., Viel G., Sauvé S.
Title Development of markers and validation of diagnostic tools for screening for beryllium induced hypersensitivity
Original title Développement de marqueurs et validation d'outils de diagnostic pour le dépistage de l'hypersensibilité induite par le béryllium [in French]
Bibliographic information Institut de recherche Robert-Sauvé en santé et en sécurité du travail du Québec (IRSST), 505 boul. de Maisonneuve Ouest, Montreal (Quebec) H3A 3C2, Canada, 2008. v, 20p. Illus. 23 ref. Price: CAD 7.35. Downloadable version (PDF format) free of charge.
Internet access http://www.irsst.qc.ca/files/documents/PubIRSST/R-556.pdf [in French]
Abstract Known for its high toxicity, beryllium can cause berylliosis, a serious pneumopathy, or chronic beryllium disease. The lymphocyte proliferation test (BeLPT) commonly used for detecting a worker's sensitivity to this metal offers little predictive value for the risks of contracting berylliosis. Knowing that this disease can take up to 30 years to develop in a sensitized worker, it is essential that a new effective detection tool be developed. By exploring experimental approaches, this research was able to determine the feasibility of methods for the selective characterization of target cells and the use of protein signatures on blood samples. A technique was also developed for quantifying beryllium in plasma, and the potential of complexing agents for displacing it and reversing its toxicity in cell cultures was tested. These new tools will allow a follow-up programme to be implemented for sensitized workers, mainly by providing a more precise diagnosis of the determination of their exposure to beryllium. It will also be possible to validate current standards or to define new ones based on firm assumptions.
Descriptors (primary) beryllium; hypersensitivity; immunology; exposure evaluation
Descriptors (secondary) lymphocytes; report; latency; chronic diseases; berylliosis; diagnosis; sensitization; long-term exposure; cell culture; sampling and analysis; determination in blood; description of technique; reliability
Document type E - Books, reports, proceedings
Country / State or ProvinceCanada
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Inorganic substances
Exposure evaluation