|Document ID (ISN)||108385|
|Convention or series no.
||Oltmanns J., Schneider K.
Bundesanstalt für Arbeitsschutz und Arbeitsmedizin
||Examination of the limit dose for the classification of substances as toxic for reproduction
||Überprüfung der Grenzdosis zur Einstufung reproduktionstoxischer Stoffe [in German]|
||Wirtschaftsverlag NW, Postfach 10 11 10, 27511 Bremerhaven, Germany, 2006. 65p. Illus. 70 ref. Price: EUR 10.50.
||A dose of 1000mg/kg body weight/day is generally cited in EU directives and OECD guidelines as a maximum dose for studies on reproductive toxicity. This project investigated whether this limit remained valid in cases of high levels of workplace exposure. To this end, published exposure data together with data from the MEGA database of the German Mutual Occupational Accident Insurance Association were evaluated. It was noted that exposures to ambient concentrations of volatile substances were in the 500 to 2000mg/m3 range (time weighted averages), while the inhalation exposures to aerosols and skin exposures were low. By using the appropriate extrapolation factors, the corresponding doses were calculated for animal experiments. For volatile substances, these doses were found to be considerably higher than 1000mg/kg/day. The analysis of the results together with other findings shows that the general concept of a limit dose of 1000mg/kg/day for the classification of substances that are toxic for reproduction is not suited to all chemicals.
||threshold limit values; toxic substances; Germany; antifertility effects
||report; inhalation; skin absorption; classification; reliability; toxicity evaluation; extrapolation animal man; volatile substances
||E - Books, reports, proceedings
|Country / State or Province||Germany|
||Toxic and dangerous substances
|Broad subject area(s)
||Antifertility and prenatal effects
Genetic factors in reaction to exposures
Occupational exposure limits