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Document ID (ISN)108281
CIS number 08-823
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 2008
Convention or series no.
Author(s) Middleton D.C., Fink J., Kowalski P.J., Lewin M.D., Sinks T.
Title Optimizing BeLPT criteria for beryllium sensitization
Bibliographic information Mar. 2008, Vol.51, No.3, p.166-172. Illus. 20 ref.
Abstract The beryllium lymphocyte proliferation test (BeLPT) is used to identify persons sensitized to beryllium. An expert panel was convened in 2006 to discuss the BeLPT test, and in particular to propose criteria that would actually establish sensitization. The three criteria proposed by panel members were: one abnormal result; one abnormal and one borderline result; two abnormal results. Complete algorithms were developed for each set of criteria. This study calculated and compared the sensitivity, specificity, and positive predictive values for each set of criteria. Findings are discussed. It is concluded that a single unconfirmed abnormal result is insufficient to establish sensitization for an apparently healthy person. When the prevalence of beryllium sensitization in a group is high, however, even a single abnormal BeLPT can be a strong predictor.
Descriptors (primary) beryllium; sensitization; reliability; diagnosis
Descriptors (secondary) lymphocytes; description of technique; determination in blood; sampling and analysis
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Chemical safety
Browse category(ies) Inorganic substances