|Document ID (ISN)||108281|
|ISSN - Serial title
||0271-3586 - American Journal of Industrial Medicine
|Convention or series no.
||Middleton D.C., Fink J., Kowalski P.J., Lewin M.D., Sinks T.
||Optimizing BeLPT criteria for beryllium sensitization
||Mar. 2008, Vol.51, No.3, p.166-172. Illus. 20 ref.
||08-0823.pdf [in English]
||The beryllium lymphocyte proliferation test (BeLPT) is used to identify persons sensitized to beryllium. An expert panel was convened in 2006 to discuss the BeLPT test, and in particular to propose criteria that would actually establish sensitization. The three criteria proposed by panel members were: one abnormal result; one abnormal and one borderline result; two abnormal results. Complete algorithms were developed for each set of criteria. This study calculated and compared the sensitivity, specificity, and positive predictive values for each set of criteria. Findings are discussed. It is concluded that a single unconfirmed abnormal result is insufficient to establish sensitization for an apparently healthy person. When the prevalence of beryllium sensitization in a group is high, however, even a single abnormal BeLPT can be a strong predictor.
||beryllium; sensitization; reliability; diagnosis
||lymphocytes; description of technique; determination in blood; sampling and analysis
||D - Periodical articles
|Country / State or Province||USA|
|Broad subject area(s)
||Occupational medicine, epidemiology