|Document ID (ISN)||108230|
|ISSN - Serial title
||1877-7856 - Encyclopédie médico-chirurgicale
|Convention or series no.
||Fascicule 16545 A 05, 4-2007
||Falcy M., Pillière F.
||Cytotoxic agents: Evaluation of occupational hazards
||Cytotoxiques: évaluation des risques professionnels [in French]|
||Toxicologie-Pathologie professionnelle, 4th Quarter 2007, No.157, 10p. 37 ref.
||08-0668.pdf [in French]
||Hazard evaluation by employers is a mandatory requirement for all workplaces and is also required for the use of drugs in healthcare environments. A first step of this evaluation consists of evaluating exposures. For each potential source (workplace atmospheres, contact surfaces) the means of investigation are presented together with the results obtained with cytostatic drugs. By comparing the total exposure of a healthcare worker with that of the treated patients, a safety factor comprised between 100 and 2000 can been calculated for some cytotoxic drugs. The effects of cytotoxic drugs have been widely described; they depend largely on the mode of action of these agents (activity on the cellular cycle and DNA). By comparing these effects with occupational exposures, the risk related to each effect is characterized: non specific (irritation, systemic toxicity) or specific (mutagenic, carcinogenic or toxic for reproduction). The risk of exposure is generally low for healthcare workers when preventive measures (including technical, medical and training measures) are correctly implemented.
||antineoplastic drugs; France; hospitals; risk factors; cytotoxic effects; health hazards; health care personnel
||mutagenic effects; disposal of harmful waste; antifertility effects; limitation of exposure; hazard evaluation; determination in urine; carcinogenic effects; medical supervision; encyclopaedia; data sheet; exposure evaluation
||F - Information notes, codes of practice, standards
|Country / State or Province||France|
||Commerce, services, offices
Toxic and dangerous substances
|Broad subject area(s)
||Health care services
Genetic factors in reaction to exposures