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Document ID (ISN)108230
CIS number 08-668
ISSN - Serial title 1877-7856 - Encyclopédie médico-chirurgicale
Year 2007
Convention or series no. Fascicule 16545 A 05, 4-2007
Author(s) Falcy M., Pillière F.
Title Cytotoxic agents: Evaluation of occupational hazards
Original title Cytotoxiques: évaluation des risques professionnels [in French]
Bibliographic information Toxicologie-Pathologie professionnelle, 4th Quarter 2007, No.157, 10p. 37 ref.
Abstract Hazard evaluation by employers is a mandatory requirement for all workplaces and is also required for the use of drugs in healthcare environments. A first step of this evaluation consists of evaluating exposures. For each potential source (workplace atmospheres, contact surfaces) the means of investigation are presented together with the results obtained with cytostatic drugs. By comparing the total exposure of a healthcare worker with that of the treated patients, a safety factor comprised between 100 and 2000 can been calculated for some cytotoxic drugs. The effects of cytotoxic drugs have been widely described; they depend largely on the mode of action of these agents (activity on the cellular cycle and DNA). By comparing these effects with occupational exposures, the risk related to each effect is characterized: non specific (irritation, systemic toxicity) or specific (mutagenic, carcinogenic or toxic for reproduction). The risk of exposure is generally low for healthcare workers when preventive measures (including technical, medical and training measures) are correctly implemented.
Descriptors (primary) antineoplastic drugs; France; hospitals; risk factors; cytotoxic effects; health hazards; health care personnel
Descriptors (secondary) mutagenic effects; disposal of harmful waste; antifertility effects; limitation of exposure; hazard evaluation; determination in urine; carcinogenic effects; medical supervision; encyclopaedia; data sheet; exposure evaluation
Document type F - Information notes, codes of practice, standards
Country / State or ProvinceFrance
Subject(s) Commerce, services, offices
Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Genetic factors in reaction to exposures
Health care services